The species of passion flower Passiflora incarnata, or “maypop,” as it is also known, is a plant with a wide variety of medicinal properties. Thought to be useful in treating everything from insomnia to asthma to narcotic withdrawal, it was originally used primarily to treat the conditions of “restlessness” and “hysteria,” which in the modern day translate to anxiety.
This article will examine the history of passion flower as an anxiety treatment, its potential medicinal properties, and the results of studies measuring its effectiveness in rodents and humans against other anxiety medications.
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History of Passion Flower as Treatment for Anxiety
People have long wanted natural ways to treat anxiety because medications are believed to have a lot of side effects. But the truth is that even natural medicines can have side effects, and even if they don't, psychologists do not advise using only a medicinal treatment. Make sure you take my free 7-minute anxiety test to learn more.
Indigenous Americans are the first people known to history to have found a use for Passiflora incarnata, a flowering vine thought to have originated in the Western hemisphere. The leaves, flowers and even the fruit of Passiflora incarnata were all thought to be useful (though the roots were not noted as having any special properties).
Settlers in the Americas were responsible for spreading the use of passion flower as a sedative across the world when they learned from local residents of its various medical uses. The Spanish renamed it the “passion flower” due to its striking appearance, which they assigned symbolic meanings relating to the passion of Christ. The spiky-looking ring around the flower’s center paralleled the crown of thorns, and the ten white petals symbolized the ten faithful apostles, excluding Judas and St. Peter.
Marketed as a sleep aid and mild sedative in the U.S. in the year 1978, it was taken off the market due to a lack of proof of its effectiveness. Since then, trials have been performed that seem to indicate that it is, in fact, a viable alternative to typical anti-anxiety meds, and passion flower is once again available without a prescription in most supplement stores, as well as online.
How Passion Flower Works
Within the medical community, the jury is still out on exactly how passion flower works, though various studies have shown it to be effective in cases of anxiety as will be further discussed in the following section.
The components of plant-based medicines that affect the body are collectively called “flavonoids.” Passion flower contains many flavonoids. Some evidence suggests that the flavonoids “chrysin” and “benzoflavone” may be the primary flavonoids in passion flower that are responsible for decreasing anxiety.
Chrysin and benzoflavone are believed to have the effect of increasing the amount of gamma-aminobutyric acid (often abbreviated as GABA) in the brain, much in the same way that standard anti-anxiety meds known as “benzodiazepines” do. GABA limits the “excitability” or reactivity of the brain’s neurons. This results in the calming effect that gives passion flower its reputation as a mild sedative but means that it can also disrupt mental and motor functions in higher quantities.
Studies of Passion Flower’s Effectiveness
In a study from the Universite de Metz in France, it was suggested that the flavonoids contained in passion flower were responsible for decreasing anxiety symptoms in mice that had been dosed with addictive substances and then subjected to a period of withdrawal. In another study using rats, prolonged sleeping time and lowered levels of activity were noted as significant behavioral changes.
In a trial comparing the effectiveness of passion flower to that of the scientifically accepted anti-anxiety medication oxazepam, a dosage of 45 drops per day of extract of passion flower was found to be as effective as 30 mg per day of oxazepam over a period of four weeks, with fewer short-term side effects. Though long-term studies were recommended as a follow-up to ensure passion flower’s safety, such studies have yet to be performed on humans.
Alkaloids belonging to a potentially toxic alkaloid subgroup known as “harmala” have been found in passion flower in trace amounts. This suggests that taking too much passion flower or taking it for too long could potentially be harmful, and underlines the importance of performing long-term studies.
Additionally, though this article has focused on the specific species also known as Passiflora incarnata or the “maypop” flower, it is important not to confuse this species of passion flower with Passiflora alata. Taking the extract of this type of passion flower has been revealed to have a genotoxic effect on the body’s cells. Genotoxic substances damage the genetic information within the cells, which can lead to mutations and potentially cause cancer.
When Not to Take Passionflower
Due to some of the active chemicals in passion flower, it is recommended that this supplement NOT be taken for anxiety in the following situations:
- During Pregnancy The alkaloids belonging to the harmala subgroup (specifically harman and harmaline) may stimulate uterine contractions, which makes it passion flower unsafe supplement to use during pregnancy.
- Before Surgery Because passionflower can slow neural activity, it has the potential to strengthen the effects of anesthesia to dangerous degree. It is best to stop taking passion flower two weeks before surgery, at minimum.
- In Combination With Other Sedatives Passion flower should be taken as a sedative by itself or not at all. Taking more than one sedative at a time runs the risk of slowing motor and mental functions more than is considered healthy.
For optimal effects and to avoid putting yourself in danger, take passion flower only in moderation and when you are not expecting to become pregnant, have surgery, or need to take another type of sedative.
Should You Use Passion Flower for Anxiety?
While passion flower is believed to be effective in the short term, its long-term effects have yet to be established, and very few controlled studies have shown any real results. There is a chance that passionflower's effect on anxiety is either very mild or a placebo, but many people do use it today with varying degrees of success.
If you do intend to use passion flower as a treatment for your anxiety, pay attention to the dosage to avoid any harmful effects from the harmala alkaloids. Also, bear in mind that your motor skills may be impaired by higher doses. Dizziness, confusion and lack of muscle coordination have been noted as possible side effects.
According to the studies that have been done there is little-known risk to taking extract of Passiflora incarnata, and the supplement can be effective, but it is acknowledged within the scientific community that further studies are needed.
In the meantime, make sure that you're actively looking for ways to control your anxiety that do not involve any medication. I've helped thousands of people control their anxiety starting with my free anxiety test. Take the test now to learn more about what you can do to make an impact on your anxiety symptoms
Akhondzadeh, Shahin, et al. Passionflower in the treatment of generalized anxiety: a pilot double‐blind, randomized controlled trial with oxazepam. Journal of Clinical Pharmacy and Therapeutics 26.5 (2001): 363-367.
Miyasaka, L. S., A. N. Atallah, and B. G. Soares. Passiflora for anxiety disorder. Cochrane Database Syst Rev 1 (2007).
Author: Micah Abraham, BSc Psychology, last updated Nov 22, 2017.