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How Bupropion Affects Anxiety

Sally-Anne Soameson, Psychiatrist
How Bupropion Affects Anxiety

Bupropion is a medication commonly used for mood stabilization in people with seasonal affective disorder (SAD), and to combat the cravings created by tobacco addiction. Bupropion has not been studied as an anxiety treatment and has therefore not been recommended as a treatment for anxiety alone. However, because anxiety often accompanies depression of many varieties, and because tobacco dependence and withdrawal can be cause of stress, treating your seasonal affective disorder or addiction with bupropion may have the side effect of decreasing your anxiety.

Read on to learn more about this drug's effects, and alternative ways to manage your anxiety (especially if you are having to treat other problems simultaneously and want to avoid medical complications).

Choosing Medications for Anxiety

Medicine has received an unfair reputation in the anxiety world. It does have a purpose, and can be helpful for those with anxiety. But it needs to be more of a last resort, and should never be used alone. You don't want to stop taking the medicine and watch as your anxiety comes back stronger than before. 

NRIs and Anxiety

Bupropion is an NRI or norepinephrine reuptake inhibitor. This means it increases the amount of norepinephrine, one of your body's fight or flight chemicals that occur in response to anxiety producing stimuli. For this reason, a person suffering from anxiety, but not from depression, will likely not be helped by bupropion because the fight or flight chemicals released may increase stress, rather than balancing out depression caused symptoms of feeling dull and inactive.

SNRIs, or serotonin-norepinephrine reuptake inhibitors, are often prescribed for anxiety because along with stimulating norepinephrine, they also stimulate the happy chemicals in the brain such as serotonin that can help to replace anxious feelings with feelings of contentment.

However, like cigarettes, SNRIs (and other medications that produce higher levels of serotonin) are addictive. NRIs are therefore noted as being lower risk medications for depression, and have found to be more effective than placebo in clinical trials.

Which to Treat First: Depression or Anxiety?

Anxiety is known for having a high rate of comorbidity, which means that it is often accompanied by other problems. Anxiety is often the precursor to the types of depression that drugs like bupropion are designed to treat. This is because a prolonged cycle of negative, anxious thoughts can lead to feelings of hopelessness and dejection. The negative mindset of depression promotes further negative, anxious thoughts, and so the cycle is perpetuated.

While treating depression can aid anxiety problems and treating anxiety problems can aid depression, anxiety treatments and depression treatments are notably different. While many treatments for depression are meant to stimulate the mind, treatments for anxiety instead require the mind to be calmed or tranquilized. This is why it is important to examine your medication for anxiety or for depression if you are experiencing both to make sure it will not aggravate one condition or the other.

Taking drugs such as bupropion to alleviate stressful feelings caused by the need to smoke can be helpful for anxiety. In addition, as bupropion is only a mild psychostimulant, it is a relatively safe antidepressant, and in helping to put you in a better frame of mind in a non addictive way, it (and similar antidepressants) may have the side effect of decreasing the likelihood of anxiety attacks.

However, you can also stop the problem before it starts by directly addressing your anxiety with proven methods that don't rely on the side effects of your medication for other problems.

Addressing Anxiety Alongside Other Problems

To ensure that your medications do not interact with one another in negative ways, it may be wise to take nonmedical steps to address your anxiety separately.

Here are some things you can do to decrease your anxiety that have zero risk of interacting in harmful ways with your other medication(s):

Anxiety is a formidable problem by itself and can become even more so when you need to take other medications to deal with problems like depression that can sometimes occur alongside it.

Though Bupropion is proven to be effective in treating depression and alleviating depression may help reduce your anxiety, it is advisable to look at your anxiety as a separate problem and take steps to keep it from interfering with your life.

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